Metastatic melanoma with diffuse melanosis histologically after stable response to talimogene laherparepvec therapy
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چکیده
منابع مشابه
Inflammatory melanoma in transit metastases with complete response to talimogene laherparepvec
TVEC: Talimogene laherparepvec INTRODUCTION Inflammatory melanoma was first described in 1984 in 2 patients presenting with nodular cutaneous melanomas resected from the back followed 4 to 12 months later by recurrence in the form of diffuse, indurated, erythematous skin 20-25 cm in diameter with scattered nodularity. Microscopic examination found melanoma cells in the dermis and dermal lymphat...
متن کاملTalimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
PURPOSE Talimogene laherparepvec (T-VEC) is a herpes simplex virus type 1-derived oncolytic immunotherapy designed to selectively replicate within tumors and produce granulocyte macrophage colony-stimulating factor (GM-CSF) to enhance systemic antitumor immune responses. T-VEC was compared with GM-CSF in patients with unresected stage IIIB to IV melanoma in a randomized open-label phase III tri...
متن کاملDiffuse cutaneous melanosis: rare complication of metastatic melanoma*
Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence. It is clinically manifested as a blue-gray discoloration of the skin and mucous membranes in a cephalo caudal progression...
متن کاملDiffuse Cutaneous Melanosis Associated with Malignant Melanoma.
780 Ann Dermatol Received December 10, 2014, Revised February 7, 2015, Accepted for publication February 18, 2015 Corresponding author: Joanna Mangana, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH 8091, Zurich, Switzerland. Tel: 41-44-255-3155, Fax: 41-44-255-454, E-mail: johanna. mangana@ usz.ch This is an Open Access article distributed under the terms of the Cr...
متن کاملIndirect Treatment Comparison of Talimogene Laherparepvec Compared with Ipilimumab and Vemurafenib for the Treatment of Patients with Metastatic Melanoma
INTRODUCTION Few randomized controlled trials have compared new treatments for metastatic melanoma. We sought to examine the relative treatment effect of talimogene laherparepvec compared with ipilimumab and vemurafenib. METHODS A systematic literature review of treatments for metastatic melanoma was undertaken but a valid network of evidence could not be established because of a lack of comp...
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ژورنال
عنوان ژورنال: JAAD Case Reports
سال: 2018
ISSN: 2352-5126
DOI: 10.1016/j.jdcr.2018.01.023